Expression of an unusual acidic glycoconjugate in Leishmania donovani.

Glycobiology of Leishmania donovani.

Leishmania donovani, the causative organism of visceral leishmaniasis (VL) is one of the deadliest of the entire known Leishmania species. This protozoan parasite displays immense adaptability to survive under extremely harsh conditions. Cell surface glycoconjugates play a pivotal role in parasite virulence and infectivity. This review mainly highlights on the importance of these molecules and ...

Protozoan Parasite Leishmania donovani

Leishmania donovani leishmaniasis in Cyprus.

76 www.thelancet.com/infection Vol 9 February 2009 Nicole Léger and Jérôme Depaquit emphasise “the importance of preventing an extension of this anthroponotic species in Europe”, a point also stressed by Dujardin et al, since leishmaniasis is not placed under public health surveillance in Europe. We certainly agree with the authors that the indigenous transmission of Leishmania donovani to Cypr...

Isolation, characterization and expression of a cyclin from Leishmania donovani.

We have cloned and sequenced a DNA fragment (approximately 1 kb) containing a complete open reading frame from a cDNA library of Leishmania donovani promastigotes. The alignment of the derived polypeptide sequence and the modeling studies revealed that the protein is highly homologous to the mammalian cyclins having conserved cyclin box and substrate-docking motif. Northern blot analysis of the...

General suppression of macrophage gene expression during Leishmania donovani infection.

Within the mammalian host, Leishmania donovani is an obligatory intracellular protozoan that resides and multiplies exclusively in the phagolysosomes of macrophages. The outcome of this infection is governed by the interaction between Leishmania and macrophage molecules that ultimately effect the expression of genes within both cells. To explore the effect of this intracellular infection on mac...